I approach this topic from a somewhat different direction. My first ML, an Omega X7, came equipped with a peep sight. I decided to mount a scope to develop loads and get experience and I hunted with the scope for the first two or three seasons. My hunting is almost entirely in fairly heavily wooded areas, a shot over 50 yards is very rare.
I practiced at the range during the off-season with the peep sight to get confidence with my ability out to 75 yards or so. Then I ditched the scope entirely and went with the peep for hunting. My success was pretty good. My ranges from the stand were a little less but my shots were clean. Then something happened. I took a 40 yard shot at a broadside standing doe, going for a double lung. When the smoke cleared, she moved off, out of sight. I re-loaded, waited about 10 minutes, and got down off the stand. At the point of impact I had a good amount of blood and started tracking. It became evident that the doe was not dead and I was pushing her. Long story short(came back next day to continue tracking), I did not recover the deer. I do not know for certain why my shot was bad - I had a rest, she was standing still, the shot was not rushed, and well within my range - but my best guess is I hit a twig or something.
I've learnt that even with 20/20 vision, the naked eye simply cannot pick up every twig and stick in heavy woods, even in moderate distances of less than 50 yards. Test this yourself by looking into the thick stuff, first without magnification, then with binocs, it's surprising (at least to me) what can look like a clear shot is really a case of threading the needle through the bush. So now I use a 4x scope for my woods shooting, not because I am inaccurate with open sights, but to make sure my sightline/bullet path is clear.