Load for bison

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KTK

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I drew a bull bison tag for a reservation in SD this October.
Been working on my load, and my Lyman Deerstalker really likes the 420gr No Excuses, over a felt wad and 80gr of 777 FFG. If I go much over 80gr, my groups start to open up.
My question is, do you guys think this load has enough power for this hunt.
Guide says shots avg between 50 and 75 yards. Will be going for a heart / lung shot, no head shots.
Any input appreciated. Thanks.
 
No experience with buffs but I think as long as you put it in the vitals you will have a dead critter, that's a big chunk of lead so should penetrate as long as a big leg bones not hit, even then probably would still make it thru.
 
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