Unfortunately, I suspect that the Rifleman is constructing a new pair of his used shorts, prepared especially for me. Death, where is thy sting? :shock:
Back to the matter at hand, checking some data-- Reloder 7 will get you there (or very close), but accuracy is a known problem in times past. I'm not sure why; I'll have to revisit that with the .033" ventliner which I have not done.
No way is IMR-4198 going to do it, with a 300 gr. bullet. Not happening. There is a subtle problem that creeps in with high loads-- start going with piles of slow stuff, your effective barrel length is diminished in concert.
So, an approach is a powder that I personally have no experience with, but one of the Savage Shooters that I respect the most does. That is H322, and checks out to be just a candidate for 300 gr. bullets, assuming a .033 ventliner; a requisite. 2500 fps is still not going to happen. 2344 fps is all it has in it. But-- for a 350 gr. bullet, you can still crack 2300 fps.
I have a very good relationship with Accurate Powders / Western Powders, and Vihtavouri. With Hodgdon-- not with smokeless muzzleloading, the lab is doing nothing that I'm aware of for obvious reasons.
H322, sold by Hodgdon, is an A.D.I. made powder-- and, ADI stuff is generally good stuff. They have some of the best extrusion equipment and techniques in the world.
So, I don't know. H322 and a 350 gr. Barnes X at 2300 fps may be the ultimate ticket. No sub-bases, no nonsense. The stated static BC is .402; not much else will give you 2377 fpe @ 300 yards :shock:
Fast 350 gr. bullets is not something I care to deal with regularly-- but the .458 / 350 gr. Barnes X does drill holes for me. It just talks back way too much for my tastes.