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Pros n Cons from y'all as you post on this Thread topic. Myself for the the hunting i do the .45 n .40 are the cats meow for me n you can't beat'em with a stick. Prb's be fine if that rings your Bell. Sometimes but not often i like to reach out just a bit n clobber the snot out of a tick toter or a porker. Why ? Because i can. .45 i start with 180 gr to 350 gr, i like me some .40 cal also 175 gr up to 300 gr. Honestly i have 2 .50's n 1 .54, why because i could not find a .45 in my area other than having to have one shipped from the West coast. So i settled on one to use at the time