Several times I have had deer, or an elk, kinda close with the usual vitals covered up with whips, saplings, or twigs. The few that come to mind were inside 50 yards. I remember one years ago, I tried a traditional shot to the heart/lung area. After the shot the deer jumped a few feet then stood there, I shot it in the neck, down it went. Later while skinning I expected 2 bullet holes, only found the one. That 1st shot was deflected. Mind you it wasn’t a minefield of whips, but enough to be a concern, plus they were relatively closer to the deer, less distance to deflect, shooting a 308.
Later I had two similar scenarios, I kept my shot above the whips, to the neck, much better results. These were both under 50 yards.
In general, if I’m shooting at a nice buck, I don’t screw around, right to the heart/lung area. Of course when out hunting, shots offered vary a good bit. That can even vary up to the point where no decent, workable shot is offered. I know it can happen, but I really try to avoid wounded game running off, unrecovered. Most places don’t have enough big bucks where one can afford to be wounding any.