I've had excellent results with 250 gr Partitions, 225 gr Accubonds, and 225 gr Triple Shocks on game all animals just went down.
Punched paper with some 225 gr Speers but not hunted with them. Their accuracy was good but I never finished the load development.
My Whelen is a custom build on a M98 action using a Shilen barrel and I love it. My longest was with the 250 Partition on a big 10 pt whitetail at 265 yards. I think he moved 2 steps before falling over, destroyed both shoulders.