I am respectfully not in total agreement with the above posts. Having had 5 previous 1:48 rifles and currently using one 1:48 (all 50 cal) my experience has been different. Starting current and working back, this rifle will not shoot PRB with any decent accuracy past 35 yards. I've used the Dutch Schultz system, tried different ball sizes, patches and lube. Literally hundreds of combos. One combo looks great on the 25 yard target and is reasonable for about another 10 yards. After that, forget it. There may be a magical combo out there somewhere but I spent so many weeks and dollars trying to find it that I could have bought another rifle easily. I tried conicals and found one particular brand and weight that this rifle puts into small groups at 100 yards. Going back to the next most recent, it would shoot one combo with PRB very accurately making nearly one-hole groups at 50 yards and a respectable group at 100 yards. However this one combo had a muzzle velocity of around 1425 fps with a 177 gr ball and subsequently quite a trajectory curve. I wanted more velocity and a flatter shooting rifle than the performance it was accurate with. Next rifle back, it shot nicely with .495 balls and a .018 patch. While the rifle did its job without too much fuss, I was unable to get the .495 balls in the stores that carried ML supplies. Sure, I could order a pile of them or make them myself but at the time I could neither stockpile nor create. Due to this inconvenience I sent that rifle to a new home. The last two I will summarize in general terms because it was a long time ago. Both shot PRB very well. One I have no idea what size balls or patches, as I shot what came with the rifle. I did not know much about BP them and I just loaded 100 grains of Pyrodex because that's what I had heard at the time. The other rifle I remember shooting every day for a month before deer season and it still wasn't ready on time. Eventually I figured out it did great if you shot about 3 shots without cleaning and started a group of 3-shots on the 4th shot. Shot 4, 5 and 6 would make a small group at 75 yards (that was the range distance at that time). I did not want to leave the gun dirty for days for fear of rust and I did not want to have to shoot 3 shots into nowhere before starting a hunt.
In summary, of my 5 rifles with 1:48, only one did what I wanted it to do with PRB loads. Some of the others were accurate with PRB loads but the nuisances to get there were not worth it to me.
On a similar note, I currently have a 1:60 .50 caliber that won't shoot PRB. It was a gift and I like the looks and feel of the rifle so I invested a whole summer of shooting and trying PRB combos. After hundreds of dollars and probably over 100 hours I gave up. On a whim I tried a projectile called a Hornady PA Conical. 1.5" groups at 50 yards on the first attempt. I have not desire to keep messing with PRB for this rifle in spite of the 1:60 twist. The PA Conicals were $9.99 for 50 and don't need a patch or lube to group great. Each rifle is unique and a thing unto itself!
Best of luck!