Last few seasons I prefer 300 over 250. I like the HORNADY XTPs .452 300 MAGs. Harvester .452 crush ribs. 115 gr by vol Blackhorn 209. Every deer i have shot with them i have recovered usually no tracking. Maybe 30yds at most.
The .430 300gr xtps have worked well with both mmp sabots or Harvester green crush rib sabots 120gr charge of blackhorn from a knight 50 cal mountaineer.