I have a Knight Disc Extreme in .52. Just stock up on a supply of bullets from Knight and keep a stock pile.
I have been shooting the 375 gr. Red Hot bullets in front of 120 grains of Triple 7 and I have been impressed with the downrange accuracy. Since I hunt in the west on the plains, I use a 150 yard zero with a high projectile path of 2.75 inches at 75 yards and a drop to -2.60 at 175 yards. Any change in bullet or powder will dramatically change these computations.
This is combined with a Nikon ProStaff 3-9x40 with their BDC. Although the scope has been fine on both a Remington 7mm magnum previously and now the Knight, I will be replacing it with another scope soon. I prefer stadia lines as opposed to the circles for longer ranges. I also want to be able to dial in range- so I need another scope. I am actually considering the Super Sniper 6x40 which has a Mil-Dot reticle. I will add a Kenton dial for specific ranges utilizing the same load. This should give me the best of both worlds.
Do the math for your rifle, combine it with a good scope and reticle, then shoot the distances to confirm. Pay special attention to how the math changes based on the power setting of your scope if it is a 2nd FP scope. Because of those changes, my Nikon is set at 6x and I only shoot at that setting so I do not have to contend with the sometimes huge (ballistic) differences in the impact point per aiming circle based on the various power settings.
It is always fun to find, modify and then use the set up for yourself. Decide what you need and there are plenty of tools out there to make it happen.
Good hunting,