There are pros and cons to using fillers, but I've done it for years. Fillers are like yer powder, you have to keep it dry. Moisture is your enemy, but here in Wyoming the air is always dry and it works for me. I shoot the 45-70 with a combination load of 4198 topped off with Cream O' Wheat under a Lee 405 grain .457 bullet that I cast from a mixture of WW and range lead. I place an over-powder vegetable wad to keep the 4198 from mixing with the filler and top to within 1/4" of a full case with the COW. This allows a little bit of compression when seating the bullet to depth and holds everything in place. The load I use Chronys at about 1650 fps. My CVA Apex single shot likes it and groups about 1-1/2" at 100 yds. with a 4.5 power scope, which is about all my old eyes can do nowadays.