Joe Name and Ron Name are far better qualified to answer what they have seen the best results with, in their barrels, with over the many years they have been offering them.
I'd personally look at a 1:24, or a 1:26 for 300 gr. bullets.
For 250 gr. class bullets, I'd look more at 1:28 or 1:30.
Naturally most all of the powder, bullet, and sabot testing I've done has been with a Savage and 1:24 twist barrels. The Savage was designed around 300 gr. bullets.
Some consideration has to be given to the velocity that you intend to shoot. No way would I want anything tighter than 1:24, regardless of .45 or .50 caliber.
Henry and Bill Ball have shot custom sabot-less smokeless muzzleloaders for years. The sabot out of the way, they shoot 1:18 barrels.