There just seems to be more options for a .45. From .357 up to and including some .458 bullets, with the right sizers and/or sabots. Although, i have some .45 bullets that won't shoot well in any of my guns so Im going to sabot them and try them in a .50. But i have a couple lead bullets that shoot well as cast and some Parker's and Thor's can be bought at the size you need. Sizing is cheap and easy. Accuracy inside 300, idk, probably similar between .45 and .50. If you just want to shoot 'off the shelf' bullets, then .50 is plentiful and several great options. I have one .50 right now and that gives me an option of shooting the Barnes in heavier weights than I can get them in for the .45 which i like for hunting.