Very few have done it in a 50cal. Bullets for the 50S&W are the best choices and there is a little bit of load data on Dougs, Savage does prohibit doing it though and without pressure tracing transducers you are in mostly uncharted territory.
Lighter 50cal bullets like 300gr for 50A&E are going to have a short bearing surface and a terrible BC so you wont gain anything other than a 50cal entrance hole. The 50-300gr FTX though might work. It works great in my 54cal sub gun in sabots. The copper Barnes options are longer for their weight but monolithic bullets can be even harder to achieve good groups. Sizing will likely be another PITA due to the small selection of sizing dies and the fairly large bore in many Savages.
Considering the pressures are likely going to be much higher than a sabotted smokeless load with the same weight bullet, i would use BH209 if you really want to give it a shot. Using BH209 ive seen it done with the 50-300gr FTX in other sub guns. Ive seen it used in 45cals and a properly sized 350gr bullet with extremely nice pressures and great accuracy.