The .4515 300 grn Sierra shot well out of a Black Diamond I had and I have killed a couple deer with the bullet. It did very well but I will say the deer were not very big--dressed weights were probably in the 90 lb range.
I like the bullet, but have been using the .430 300 XTP the last few years just because I have a lot of confidence in it.
With MMP hph24 sabots and the .4515 300 Sierras and 777 my Omega shoots very well though. If it was the most accurate in my rifle I'd hunt with it.