I use the anti-seize and/or tape on White Bison + black powder, 3 different nose kit and plugged rem 700ML + BH209, 2 Savage ML2 with smokeless, custom barreled Omega with smokeless, factory barrel Omega with BH209. The Bison and factory Omega have original breech plugs all the others have Savage type plugs with vent liners.
Believe me that heavy loads of 4198 or BH209 in a 45 or 50 will test your plug and vent liner anti-seize. W