Back when, I used 2 50g Pyrodex pellets and a 275 great Powerbelt in G2 .45. Good accuracy and great knockdown for deer. I felt like it replicated my prior set up, Cherokee, 80 grains loose Pyrodex and the now extinct Hornady Great Plains 285, for accuracy and impact. Both setups good at 100yds. Now resurrecting the G2 with 70 grains 777, 180 XTP. My experience is that lighter powder charges work great in .45s.