I've found that the 22 twist was no more nor less accurate than the 28 twist 45 cal when shooting the 200SST with Harvester sabots. The MMP sabots were less accurate and affected by temp more. The 22 twist will shoot as fast as one should care to shoot the 200SST and stay accurate. Its primary advantage should be to shoot longer 40/357 cal bullets than the 200SST. In spite of that, the 28 twist is shooting the 357 195g DCs @ 2300 '/sec at well below 1 MOA with very little recoil. Haven't tried these in the 22 twist yet. I do have some 180g/40 cal "The Bullets" that are quite long, and plan to test them extensively in the 22 twist. I think the 22 and 28 twist barrels will both work well; but if I were ordering a 45 cal barrel/gun, I'd likely select either a 28 or 32 twist barrel. I just have a gut feeling that either would be good choices, especially if 200SW/SSTs were the projectile of choice.