I started weighing my charges in the last few months and found the weighed charges reduced my 100 yards group by about 1 to 1 1/2 inches. Weighed charges eliminated "vertical stringing" in the groups and reduced the number of flyers.
When I was playing around with my powder measure set on 100 grains volume and Pyrodex FFG, I found I could get a variance of as much as 13 grain weight, depending on how I filled the measure (tapping it, shaking it, holding it very steady, leveling it off, leaving it rounded, etc.)
Here's what I got with my adjustable brass powder measure set at 100 grains volume. Filled it with each type of powder, tapped the side of the measure with a pencil six times to settle the powder (it settled about 1/4"), then filled it again to overflowing, tapped it down again twice, then leveled it off and weighed it.
Goex FFG weighed 110 grains even.
Pyrodex RS weighed 78.0 grains.
Pyrodex Select RS weighed 76.7 grains.
Triple Seven FFG weighed 77.8 grains.
Triple Seven FFFG weighed 87.0 grains.
I'm at the point where I'll only shoot volume charges when I'm playing around. Serious target work and hunting - I use weighed charges.