I started out taking full advantage of the "magnum" rifle and shot 150 gr. of 777 and 400 gr. pure lead bullets for elk. It was brutal to shoot, and the bullets expanded to over an inch, and didn't exit. I believe that cost me a few elk. A pointed bullet that doesn't expand has a great b.c., but doesn't leave a blood trail. I often shoot at over 200 yards, so I wanted a good trajectory and energy. I've since switched to a flat nosed 405 gr, .45-70 bullets and 115 gr. 777. That usually drops the elk in their tracks. For deer, I still like heavier bullets arouund 300 gr. and go with about 100 gr. 777. I have found that the Precision Rifle Dead Centers work very well. The reason most people recommend loose powder is because you can change the amount and see what shoots best in your rifle. Changing bullets and powder changes group sizes, and there are so many possible combinations, I won't try them all in my lifetime.