Sight it in how you are going to be shooting it mostly (particularly if it isn't free floated). if an off hand rifle, you can rest your hands on a bag in the spot where you are normally going to hold it. If it's a bench gun, use whatever bipod or directly rested bag arrangement you are planning to use.
Otherwise, do some research on what trajectory your loading is most likely traveling on out to your selected distance, and set up a target on grid/graphing paper at 25 yards to have a black aiming point, and a light gray (so you can't really see it when shooting) impact point on the target. Aim at the black, adjust so you hit the impact area. Saves a lot of walking, stray shots, and frustration when it comes time to fine tune the sighting at the true distance you want. (ballistic calculators give you trajectory in +- inches from line of sight (your aiming point)).
on my open sighted guns with folding leaves, it saves a heck of a lot of walking lol.