I haven't found good results at 200 to be difficult to obtain. My old Omega Z5 would keep 3 under 1 1/2 inches with the Hornady 44 caliber XTP, both 240 and 300 grainers, at muzzle velocities of 1700 fps for both, using Triple 7. My Black Diamond XR 50 caliber stayed under 3 inches at 200 with 45 caliber XTP's 250 and 300's at 1550 and 1600 fps using Swiss black. She as aperture sighted not scoped like the Z5.
On the Omega, I used the duplex reticle and power adjustment to compensate for hold over. I shot a group and adjusted the mag until the fine crosshair was on the aim point and the tip of the thick hair was in the group. Then using the tip of the thick hair as my crosshair, the next 3 went right on the money. For hunting, ethically, you will need a range finder and must know your drops.
Haven't done any work at 200 with my Super 45 XR yet. I don't shoot heavy charges, but the drop chart shows a much flatter trajectory than the 50. The 45 has also oven to be a wee bit more accurate and a lot easier on the powder and shoulder.