Pheonix sorry but the answer is..NO!
I was thinking this very thing as I like these bullets too. Before I did it though I spoke with Sabotloader about it. He spoke to Lehigh Dave and Dave told him that the Bloodline and the Lehigh CF is ONLY for muzzeloaders. The Problem here is that the Brass in the Bloodline (I have and shot the 275) and the Copper in the CF (What I shoot now) are too hard and will not engrave and or obturate in the bore of the CF rifle but instead will become an obstruction and that could be catastrophic. I lost the actual info in our PM when the site changed over. Maybe Sabotloader will see this and correct me if I posted something not quite right. Bottom line is that Lehigh will say "don't do it with their CF or Bloodline they are for Sabots in muzzle loaders only".
Lehigh Does make a 245gn Penetrator that is specifically for the 450BM. The Design and the way it works are different. I am thinking of trying it but have not quite decided yet. I did actually try to seat one (265CF) in a case and it crushed the case but that was more from not Expanding it enough as you would for a 250gn FTX.
https://www.lehighdefense.com/colle...r-xtreme-penetrator-bullet?variant=1097146160