I think this is one of those debates that can be argued back & forth like the bible.
Good shooters, with lots of time behind their scoped rifle, can sight in with a particular powder, powder charge, wad, & sabot/bullet, or lead conical, or copper, or brass projectile; for a maximum point blank range, and after ranging the distance to the animal, hold over, or under, within the rise/drop of the bullet, and feel perfectly confident of ethically killing their chosen game.
It's called experience, and there's nothing wrong with it.
OTOH, precision target shooters, by nature, will want to use a range finder, and dial in the exact number of M.OA.'s in their scope so that, what they see as "guesswork,", is eliminated.
Personally, I won't try to kill any animal at any range, whether I consider it table fare, or vermin, without being 99.999% sure that it's going to be a killing shot when I pull the trigger.
Hunting of animals for the table, for me, means not shooting past 75-100 yards, regardless of what projectile is coming out of the muzzle.
Personally, I consider shooting game animals at long distances to be the antithesis of hunting. I know that this is a very unpopular opinion in this day and age. But, I was raised that the concept of hunting took place on the ground, by a mobile, slowly moving hunter, who was actively pursuing his intended prey. At the very least, you created a ground blind so as to ambush the animal.
In other words, the human hunter was mimicking in every possible way, the actions of the big cats, the wolves, and the other predator species of the animal kingdom.
Pulling the trigger from 125 yards, and beyond, FOR ME, goes against everything I was taught.