2 Pellet loads can tend to cause Some of the pointy bullets to not expand properly, it just don't push them fast enough. Having said that I agree with Tom and Fred on the Loose powder. Just need a bottle funnel and a volumetric powder measure and pour it in a lanes tube. There is no real mystery in using loose powder. I will add that those Boxes for the pellets are not sealed so can draw moisture, so take care with storage especially after the season is over. When loading with them watch for cracked pellets, as mentioned, and when seating a bullet with sabot you just run it down and till it stops on the pellets and make sure it is firmly seated but not so much you break the pellets.
Having said this, My Nephew is shooting an early model Wolf and I could not get him to switch to loose. He is shooting 2 777 50x50 Pellets, Hornady 45cal 300gn XTP (regular not mag) in a Black Crushrib sabot. That load has taken several whitetails out to 175 yards no problem. His Wolf loves that load.